What Is The Most Important Information I Should Know About RADOSKING?
Do not take RADOSKING if you:
- take medicines called ¡°nitrates¡± such as nitroglycerin or other medications like isosorbide dinitrate or isosorbide mononitrate, which are often prescribed for chest pain as the combination may cause an unsafe drop in blood pressure; or use recreational drugs called ¡°poppers¡± like amyl nitrite and butyl nitrite.
- take medicines called guanylate cyclase stimulators such as riociguat (Adempas),* a medicine used to treat pulmonary hypertension as the combination may cause an unsafe drop in blood pressure.
- are allergic to RADOSKING,or any of its ingredients. Call your healthcare provider or get help right away if you experience any symptoms of an allergic reaction, such as rash, hives, swelling of the lips, tongue or throat, or difficulty breathing or swallowing.
     After taking a single tablet, some of the active ingredient of RADOSKING remains in your body for more than 2 days. The active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications.
     Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex. Sexual activity can put an extra strain on your heart, especially if it is already weak from a heart attack or heart disease.
What Should I Tell My Healthcare Provider Before Taking RADOSKING?
RADOSKING is not right for everyone.
Only your healthcare provider and you can decide if RADOSKING is right for you. Ask your healthcare provider if your heart is healthy enough for you to have sexual activity. Do not take RADOSKING if your healthcare provider has told you not to have sexual activity because of your health problems. Before taking RADOSKING, tell your healthcare provider about all your medical problems, particularly if you have or ever had:
heart problems such as chest pain (angina), heart failure, irregular heartbeats, or heart attack pulmonary hypertensionlow blood pressure or high blood pressure that is not controlledstrokeliver or kidney problems or require dialysisretinitis pigmentosa, a rare genetic (runs in families) eye disease severe vision loss, including a condition called NAION stomach ulcers or a bleeding problema deformed penis shape or Peyronie¡¯s disease an erection that lasted more than 4 hours blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia.
Can Other Medicines Affect RADOSKING?
Tell your healthcare provider about all the medicines you take, especially:
medicines called "nitrates" which are often prescribed for chest pain medicines called guanylate cyclase stimulators, such as riociguat (Adempas), used to treat pulmonary arterial hypertension and chronic-thromboembolic hypertensionalpha-blockers often prescribed for prostate problems blood pressure medications medicines for HIV or some types of oral antifungal medications some types of antibiotics such as clarithromycin, telithromycin, erythromycin (several brand names exist, please contact your healthcare provider to determine if you are taking this medicine)other medicines or treatments for erectile dysfunction (ED) RADOSKING is also marketed as ADCIRCA for the treatment of pulmonary arterial hypertension. Do not take both RADOSKING and ADCIRCA.
How Should I Take RADOSKING?
RADOSKING should not be taken more than one time each day. If you miss a dose, you may take it when you remember but do not take more than one dose per day. Take RADOSKING exactly as your healthcare provider prescribes it.
What Should I Avoid While Taking RADOSKING?
Do not use other ED medicines or ED treatments.Do not drink too much alcohol (for example, 5 glasses of wine or 5 shots of whiskey). Drinking too much alcohol can increase your chances of getting a headache or getting dizzy, increasing your heart rate, or lowering your blood pressure.
What Are The Possible Side Effects Of RADOSKING?
The most common side effects with RADOSKING are:
headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Men who get back pain and muscle aches usually get it 12 to 24 hours after taking RADOSKING. Back pain and muscle aches usually go away within 2 days. Call your healthcare provider if you get any side effect that bothers you or one that does not go away.
Uncommon but serious side effects include:
An erection that won¡¯t go away: If you get an erection lasting more than 4 hours, seek immediate medical help to avoid long-term injury.
In rare instances, men taking prescription ED tablets, including RADOSKING, reported a sudden decrease or loss of vision or hearing (sometimes with ringing in the ears and dizziness). It¡¯s not possible to determine if these events are related directly to the ED tablets or to other factors. If you have a sudden decrease or loss of vision or hearing, stop taking any ED tablet, including RADOSKING and call a healthcare provider right away.

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 PP-TD-US-0311 1/2016  Important Safety Information